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Vitamin B12 is considered very safe because it's water-soluble, which means your body usually flushes out extra amounts through urine

[DOI] [PubMed] [Google Scholar] 138.Wanahita N., Messerli F.H., Bangalore S., Gami A.S., Somers V.K., Steinberg J.S

doi: 10.3389/fnut.2026.1730639 Received 23 October 2025 Revised 31 December 2025 Accepted 05 January 2026 Published 03 February 2026 Volume 13 - 2026 Edited by Ferenc Budan, University of Pcs, Hungary Reviewed by Junpeng Wang, Henan University, China Haoran Mu, Shanghai General Hospital, China Updates Copyright 2026 Tian, Zhu, Zhang and Liu

FIGURE 4 Mitochondria are central to the process that couples glucose metabolism to insulin exocytosis, and their dysfunction is an early feature of diabetes (Supale et al., 2012)